Current Issue : July-September Volume : 2011 Issue Number : 3 Articles : 12 Articles
Various species of genus Tephrosea have been extensively studied for their pharmacological activity. Tephrosea purpurea is expected to possess many constituents among them triterpenoids are also major constituents. So deu to presence of triterpenoid Tephrosea purpurea may possess Anthelmintic activity. In the present work ethanolic and aqueous extract of leaves of Tephrosea purpurea were evaluated for its Anthelmintic activity against earthworm and tapeworm at three different concentrations (25, 50, 100 mg/ml). The Anthelmintic activity of both extracts was comparable with standard drug (Piperazine citrate, 50 mg/ml) having same concentration. Animal treated with distilled water was taken as a normal control. Standard drug solution was prepared in distilled water. Activity was evaluated by noting the time required for paralysis and death of worms by extracts. The data shows that ethanolic extract (100 mg/ml concentration) possess comparable anthelmintic activity with standard drug. The results show that the plant has the potential to be used as Anthelmintic....
The present study was designed to assess the effect of methanolic and aqueous extracts of Oroxylum indicum (family: Bignoniaceae) leaves in alloxan-treated diabetic rats. The leaves of Oroxylum indicum were extracted using methanol by soxhlation and water by maceration process. The extracts were evaluated for acute toxicity in mice. Diabetes mellitus was induced by intraperitoneal injections of alloxan (120 mg/kg). The diabetic animals were orally treated with methanolic and aqueous extracts (300 mg/kg b.wt.) for 21 days. Glibenclamide was used as a reference drug at a dose of 10 mg/kg b.w. Fasting blood glucose level, lipid profile, biomarkers enzymes, serum total proteins, serum creatinine and serum urea were evaluated in normal and diabetic rats. The 21-day treatment with extracts resulted in significant decrease in blood glucose level. Elevated serum glutamate oxaloacetate transaminase (SGOT), glutamate pyruvate transaminase (SGPT), and alkaline phosphatase (SALP) were diminished significantly by the treatment of methanolic and aqueous extract in respect to diabetic group. Also there was significant decrease in serum triglyceride, total cholesterol, protein, urea and creatinine levels in treated groups. The methanol extract induced more significant antidiabetic effect than the aqueous extract....
In this article, flavonoid content, total phenolic content and antioxidant activities of Hydroalcoholic extracts of the Root of Ipomoea turpethum were measured. Total phenolic content was assessed by the Folin–Ciocalteau assay whereas antioxidant activities were assessed by measuring the ability of the extracts to scavenge the Super oxide free radical and DPPH Free radicals, reducing power Method by FeCl3, Phosphomolybdenum assay (P–Mo). Total Phenolic content and Flavanoids content of Hydroalcoholic (50%) extract of Root of Ipomoea turpethum (1mcg/ml) was found to be 27.469±0.539 mcg/mg of Gallic acid equivalent to phenol and 296.667±0.0010 mcg/mg of Rutin equivalent respectively. This extract exerted significant antioxidant activity as evidenced by its DPPH free radical scavenging (IC50=329.469± 0.934 μg/ml), The reducing power of Ipomoea turpethum Hydroalcoholic (50%) extract increased with increase in concentration and superoxide free radical scavenging activities (IC50=91.456±3.75 μg/ml.). The results obtained in the present study indicate that Ipomoea turpethum is a potential source of Antioxidants....
The present study was planned to evaluate the antipyretic activity of ethanolic leaf extract of Carica papaya Linn. in albino rats following oral administration. Plant extracts were administered at the doses of 100 & 200 mg/kg body weight. The standard drug used was paracetamol (200mg/kg p.o). Rectal temperature of experimental animals was recorded at a time interval of 1hrs, 2hrs, 3hrs, and 4hrs after drug administration for evaluation of antipyretic activity. The results showed that the ethanolic extract significantly reduces fever at higher doses within 2 hrs. on yeast induce hyperthermia in rats....
The leaves of Chinopodium album Linn. Family Chinopodiaceae have been used in Ayurvedic medicine since ancient times for the treatment of male sexual disorders. The present study is aimed to investigate the effect ethanolic extract of bathua on general mating behaviour, libido, and potency along with its likely adverse effects on sexually normal male Swiss Albino mice. The suspension of the extract was administered orally at the dose of 100, 250, and 500 mg / kg v/v, to different groups of male rats (n = 6) once a day for seven days. The female albino mice involved in mating were made receptive by hormonal treatment. The general mounting frequency, libido and potency were determined and compared with the standard reference drug sildenafil citrate. The probable gastric ulceration and adverse effects of the extract were also evaluated. The hormonal parameter like testosterone was evaluated. Oral administration of the extract significantly increased the Mounting Frequency and increase in sex hormone testosterone was estimated. The most appreciable effect of the extract was observed at the dose of 500 mg/kg. The test drug was also found to be devoid of any conspicuous gastric ulceration and adverse effects. The results indicated that the ethanolic extract of Chinopodium album Linn. Family Chinopodiaceae produced a significant and sustained increase in the sexual activity of normal male mice, without any adverse effects. Thus, the resultant aphrodisiac effectivity of the extract lends support to the claims for its traditional usage in sexual disorders....
An ethno botanical study about Passiflora incarnate L an indigenous to an area from the southeast US to Argentina and Brazil. It is cultivated in Europe. This accounts for many ethnical uses in the study area. The folk communities use the various parts of it for the treatment of their different ailments and diseases treat boils (root), inflammation and wounds (briers or locusts), liver problems (roots), Sedative, nervous anxiety, hysteria (leaf) chewing gum (leaf)....
Boerhaavia diffusa Linn. (Punarnava) is a medicinal plant belonging to family Nyctaginaceae. It has many pharmacological activities like anti-convulsant, anti-hepatotoxic, anti-inflammatory and diuretic etc. Convulsion is the chronic disorder of the central nervous system manifested by recurrent unprovoked seizures. The present study was undertaken to investigate the anticonvulsant efficacy of the root extract of Boerhaavia diffusa Linn. using Maximal electroshock induced seizure(MES) in wistar albino mice. In this method, the animals were divided into four different group of six animals each. The different group were treated with different treatments and doses orally i.e. , 1% normal saline(1 mg/kg.), phenytoin(3mg/kg.), methanolic extract at high dose(1500mg/kg), methanolic extract at low dose(500mg/kg.). The methanolic extract showed significant Anticonvulsant activity at P< 0.05 by abolishing the tonic extensor phase when compared to control group. The % inhibition and % mortality were observed. The methanolic extract at dose level (1500mg/kg. p.o.) was gave 73.73% protection against the MES (maximal-electroshock) induced convulsions and 0% mortality....
The hypoglycemic activity of the ethanolic extract was evaluated in alloxan induced diabetic rats by single dose of 100mg/kg body weight. Antihyperglycemic activity of the extract was also evaluated at the same dose levels in alloxan monohydrate (80mg/kg s.c.) induced diabetic rats during a 15 days treatment period. Glibenclamide (4.5mg/kg) was used as the reference drug. Fasting blood glucose and sarum parameters triglycerides, total cholesterol, HDL cholesterol levels were measured acute oral toxicity of theNymphaea lotus rhizome extract was carried out in swiss albino mice.\r\nIn diabetic rats, ethanolic extract showed a significant (P<0.05) decreased the blood glucose level in a dose dependent manner during the 15 days of the treatment period. In the acute oral toxicity study, Nymphaea lotus showed no mortality. The present investigation shows that Nymphaea lotus rhizome has potential anti diabetic effects....
This paper deals with the detailed pharmacognostical evaluation of the Echinochloa crusgalli (Linn.) Beauv. (Gramineae, Poaceae). Morphology of the entire plant have been studied with the aim to aid pharmacognostic and taxonomic species identification using light and confocal microscopy, WHO recommended physio-chemical, morphological and histological parameters presented in this paper may be proposed as parameters to establishes the authenticity of Echinochloa crusgalli (Linn.) Beauv. and can possibly help to differentiate the drug from its other species /varieties....
Parkinsonia aculeata family Fabaceae is highly reputed ayurvedic medicinal tree commonly known as the Ram Baval. It is a medium sized tree (4–6m), native to tropical America, extending from Mexico to South America. In India it is now completely naturalized in all dry regions, particularly western parts. The different parts of this plant contain number of Phytochemical like alkaloids, glycosides, flavonoids, steroids, saponins essential oils etc. Various parts of this plant such as leaves, roots, seed and bark, possess anti-malarial, anti-inflammatory, hypoglycemic, anti-amoebic, hepatoprotective and anti-spermatogenic activity. Various phyto-pharmacological evaluations have been reported in this literature for the important potential of the Parkinsonia aculeata...
Ulcerative lesions of the gastrointestinal tract are major side effects associated with the use of NSAID’s, alcohol, stress, and ischemic reperfusion. The anti-ulcerogenic activities of many plants product are reported due to increase in mucosal defensive factors rather than decrease in offensive factors. The present study was designed to investigate the anti-ulcer efficacy of a polyherbal drug; Acisim by employing ethanol (80%) induced acute gastric ulceration in rats. There was a significant (p<0.001) decrease in ulcer index and antioxidant parameters in the rats treated with acisim compared to the standard drug Omeprazole. These results suggest that the aqueous form of Acisim possesses potential gastroprotective and antiulcer activity which may be attributed to their antioxidant mechanism....
The reported prevalence of coronary heart disease in adult surveys has risen four-fold in 40 years and even in rural areas the prevalence has doubled over the past 30 years. Modern medicine, so far, does not have definite cures, and those offered by it have many side effects. Hence, herbal products need to be evaluated scientifically with an aim to define the role of these agents in alleviating cardiovascular disease. Plants used for the treatment of cardiovascular disease include Terminalia arjuna, Vitis vinifera, Lagenaria siceraria, Pichrorrihiza curroo, Centella asiatica, Ginko biloba, Cucumis trigonus, Punica granatum, Crocus sativus, Sida cordifolia etc. Polyherbal formulations give synergistic effect if given in proper dose and quantity. The present review focused mainly on use of individual plant, mechanism of action and polyherbal formulations for the treatment of cardiovascular disease....
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